Mycobacterium avium subsp. paratuberculosis and Salmonella Dublin are both infections that lead to economic losses and decreased animal well-fare. Further, Salmonella Dublin is the cause of serious invasive infections with a high case mortality risk in humans. The infections have several features in common. They spread mainly via the faecal-oral route or intake of infected milk, and may spread from animals that do not show signs infection. Control measures against both infections frequently should be focused on calf and calving management. Salmonella Dublin is included in a surveillance program in Denmark, whereas paratuberculosis is not. This has increased the desire to intervene against Salmonella Dublin. Due to the common infection routes and the assumption that most of the approximately 1000 dairy herds that are infected with Salmonella Dublin also have paratuberculosis, it was decided to include both infections in a manual for advisors. This manual serves as a practical tool to effectively plan control measures against both infections. The approach has lead to increasing knowledge and interest in intervention against paratuberculosis among farmers.The primary aims of the manual are: a) to serve as a learning tool for the farmer; b) to establish a practically feasible control plan. The manual is based on risk assessment of all important routes of transmission. Subsequently, a detailed plan on measures to be taken in the specific herd to limit the spread of infection is established. The plan includes testing, where test results are used by the farmers to establish management lists. Since culling is not always possible or advisable if the test-result is uncertain, animals are included in the management lists as high-risk animals. These animals are to be treated as high-risk animals at calving and at milk feeding, whereas others can be treated as low-risk animals.