The prevalence of ruminant paratuberculosis has been well delineated in states of the eastern and midwestern United States. In these areas paratuberculosis is predominantly described as a disease of Holstein dairy cattle with some involvement of Bos taurus beef cattle. In Louisiana, the disease distribution is different in that paratuberculosis is seen predominantly in Bos indicus or Bos indicus crossbred beef cattle. It is seen rarely in dairy cows. The major reason for this difference in distrubiton is probably that in Louisiana, beef cattle are the predominant ruminant with approximately 6 beef cows for every dairy cow in the state. Of the beef cows, Bos indicus or Bos indicus crossbred animals are the most numerous breeds. The prevalence of paratuberculosis in Louisiana has been examined by serosurvey, by owner recognition questionnaire, and by a slaughterhouse study. Clinical case surveys and necropsy evaluations have been conducted on all animals submittted to the LSU/SVM VTH&C over the past 10 years. Prevalence, clinical and pathologic findings will be described.