Hoek A, Rutten VP, van der Zee R, Davies CJ, Koets AP. Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattle. Vaccine 2010 Aug 16;28(36):5910-9.

 

Koets A, Santema W, Mertens H, Oostenrijk D, Keestra M, Overdijk M, et al. Susceptibility to paratuberculosis infection in cattle is associated with single nucleotide polymorphisms in Toll-like receptor 2 which modulate immune responses against Mycobacterium avium subspecies paratuberculosis. Prev Vet Med 2010 Mar 1;93(4):305-15.

 

Eisenberg SW, Nielen M, Santema W, Houwers DJ, Heederik D, Koets AP. Detection of spatial and temporal spread of Mycobacterium avium subsp. paratuberculosis in the environment of a cattle farm through bio-aerosols. Vet Microbiol 2010 Jul 14;143(2-4):284-92.

 

Santema W, Overdijk M, Barends J, Krijgsveld J, Rutten V, Koets A. Searching for proteins of Mycobacterium avium subspecies paratuberculosis with diagnostic potential by comparative qualitative proteomic analysis of mycobacterial tuberculins. Vet Microbiol 2009 Mar 20;138(1-2):191-6.

 

Santema W, Hensen S, Rutten V, Koets A. Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis. Vaccine 2009 Apr 14;27(17):2312-9.

 

Hoek A., Rutten V.P., Kool J., Arkesteijn G.J., Bouwstra R.J., Van Rhijn I., Koets AP. 2009. Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+) CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Vet Res. 40(1):6.

 

Koets A., Hoek A, Langelaar M, Overdijk M, Santema W, Franken P, et al. Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis. Vaccine 2006 Mar 24;24(14):2550-9.

 

Van Rhijn, I., V. P. Rutten, B. Charleston, M. Smits, W. van Eden, and Koets AP. 2007. Massive, sustained gammadelta T cell migration from the bovine skin in vivo. J Leukoc Biol 81:968-973.

 

Van Rhijn, I., A. P. Koets, J. S. Im, D. Piebes, F. Reddington, G. S. Besra, S. A. Porcelli, W. van Eden, and V. P. Rutten. 2006. The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d. J Immunol 176:4888-4893.

 

Koets A., Rutten V, Hoek A, van Mil F, Muller K, Bakker D, et al. Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect Immun 2002 Jul;70(7):3856-64.

 

Koets AP., Rutten VP, de Boer M, Bakker D, Valentin-Weigand P, van Eden W. Differential changes in heat shock protein-, lipoarabinomannan-, and purified protein derivative-specific immunoglobulin G1 and G2 isotype responses during bovine Mycobacterium avium subsp. paratuberculosis infection. Infect Immun 2001;69(3):1492-8.

 

Koets, AP., G. Adugna, L. L. Janss, H. J. van Weering, C. H. Kalis, G. H. Wentink, V. P. Rutten, and Y. H. Schukken. 2000. Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. J Dairy Sci 83:2702-2708.

 

Koets AP., Rutten VP, Hoek A, Bakker D, van Zijderveld F, Muller KE, et al. Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis. Vet Immunol Immunopathol 1999;70(1-2):105-15.